Endotoxaemia in Haemodialysis: A Novel Factor in Erythropoetin Resistance?

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Endotoxaemia in Haemodialysis: A Novel Factor in Erythropoetin Resistance?

BACKGROUND/OBJECTIVES Translocated endotoxin derived from intestinal bacteria is a driver of systemic inflammation and oxidative stress. Severe endotoxaemia is an underappreciated, but characteristic finding in haemodialysis (HD) patients, and appears to be driven by acute repetitive dialysis induced circulatory stress. Resistance to erythropoietin (EPO) has been identified as a predictor of mo...

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Harrison, Laura E.A. and Burton, James O. and Szeto, Cheuk-Chun and Li, Philip K.T. and McIntyre, Christopher W. (2012) Endotoxaemia in haemodialysis: a novel factor in erythropoetin

Background/Objectives: Translocated endotoxin derived from intestinal bacteria is a driver of systemic inflammation and oxidative stress. Severe endotoxaemia is an underappreciated, but characteristic finding in haemodialysis (HD) patients, and appears to be driven by acute repetitive dialysis induced circulatory stress. Resistance to erythropoietin (EPO) has been identified as a predictor of m...

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Surgical procedures in patients with obstructive jaundice are associated with significant morbidity and mortality1. This is due, to a large extent, to the development of postoperative complications such as sepsis, bleeding disorders and renal failure24. Clinical and experimental studies have suggested several aetiological factors for these complications including hypotension, impaired nutrition...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2012

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0040209